Irish Medicines Formulary (IMF)

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Medicines Safety in Irish Nursing Homes

How IMF presents information in a powerful cascade - example: Lipid Lowering Drugs in Ireland

Medicines Administration Safety ("Rights of Medicines Administration")

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Spotlight: Lipid Regulating Drugs Licensed and Marketed in Ireland

Cardiovascular disease remains the leading cause of mortality in Ireland and hypercholesterolaemia is a major contributing factor. As a modifiable risk factor, raised serum cholesterol presents widely in primary care and doctors need to know the treatment options and medicines available. Currently, there are 5 sub-classes of medicines available for treating hyperlipidaemia and associated indications in Ireland. Each sub-class may have a number of molecules (“unique chemical entities”) within it and each molecule may be marketed as an original brand with or without generic and branded-generic equivalents.

In IMF, to ensure the health professional has a full and clear overview of the available treatment options, the information is beautifully presented in a cascade:

Class

Sub-class(es)

Molecule(s)

Original Brand(s) (Manufacturer or MAH)

Generic Equivalent(s) (Manufacturer or MAH)

Each tier of the cascade is further detailed with prescribing, safety and administration information for each drug. An example, reflecting the current status in Ireland today follows below (but see IMF for the full details).

Class: Lipid-Lowering Drugs

Statins:

Atorvastatin

Lipitor (Pfizer)

Atorvas (Rowex)
Atorvastatin (Dexcel)
Atorvastatin (Pinewood)
Atorvastatin (Actavis)
Atorvastatin (Clonmel)
Atorvastatin (Krka)
Atorvastatin (Mylan)
Atorvastatin (Teva)
Torvacol (Clonmel)

Fluvastatin

Lescol (Novartis)

Pravastatin

No Original Brand

Pravamel (Clonmel)
Pravastatin (Accord)
Pravastatin (Actavis)
Pravastatin (Teva)
Pravastatin (Mylan)
Pravat (Pinewood)
Pravitin (Rowex)

Rosuvastatin

Crestor (AstraZeneca)

Rosuva (Rowex)
Rosuvastatin (Accord)
Rosuvastatin (Actavis)
Rosuvastatin (Clonmel)
Rosuvastatin (KrKa)
Rosuvastatin (Mylan)
Rosuvastatin (Pinewood)
Rosuvastatin (Teva)

Simvastatin

Zocor (MSD)

Simtan (Clonmel)
Simvastatin (Accord)
Simvastatin (Bluefish)
Simvastatin (Gerard)
Simvastatin (KrKa)
Simvastatin (Teva)
Sivatin (Rowex)

Statin combinations:

Acetylsalicylic Acid, Atorvastatin, Ramipril

Trinomia (A.Menarini)

Ezetimibe, Atorvastatin

Atozet (MSD)

Ezetimibe, Rosuvastatin

Lipocomb (Servier)

Ezetimibe, Simvastatin

Inergy (MSD)

Ezetimibe/Simvastatin (Clonmel)
Ezetimibe/Simvastatin (Rowex)

Ezetimibe:

Ezetimibe

Ezetrol (MSD)

Ezetimibe (Accord)
Ezetimibe (Gerard)
Ezetimibe (KrKa)
Ezetimibe (Rowa)
Ezetimibe (Teva)

Fibrates:

Fenofibrate

Lipantil Micro Supra (Mylan)

Gemfibrozil

Lopid (Pfizer)

Anion exchange resins:

Colesevelam

Cholestagel (Genzyme)

Colestyramine

Questran Powder Sachet (BMS)

Omega-3-fatty-acids:

EPA,DHA

Omacor (Mylan)

The example above indicates the style, format and type of content available in IMF. Of course, the book (IMF) and the digital version (IMF-Online) include much more information.